Top Definition
A popular sign-off/closing for television interviews or podcasts. The phrase originally became an internet sensation after Texas Governor Rick Perry used the phrase as a sign-off closing goodbye to a television reporter.

During the hype for Perry's speculation of running for U.S. President in 2012, it was used by a popular podcast, No Agenda, with Adam Curry and John C. Dvorak.

The Phrase generally means "Goodbye, Motherf*cker". This phrase is the exact opposite of In the Morning.
Adios, Mofo!!
by PropagateTheFormula August 05, 2011

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