Discrimination or prejudice directly aimed at able-bodied people precisely because they are able-bodied.
Steve: Look at him. Just look at him.
Steve: That guy over there. Leg-using muthafucka!
Paul: Dude! You need to calm the hell down. Someone will accuse you of ableism if they overhear.
Ableism is a form of discrimination toward people with disabilities either physical or mental. Generally, ableism prevents disabled persons from having the same access to rights and services that average people have no problems obtaining.
Disabled visitor at hotel: "I'd like to rent out a room?" Receptionist: "Sorry, all rooms are currently taken." Average visitor at hotel AFTER disabled person leaves: "Hey, I'm interested in renting a room?" Receptionist: "Sure, that'll be $500." Average person: "Here you go." Receptionist: "Here's the key, enjoy your visit. It's room 112A."
This is Ableism.