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1.
To have a penis cut off during circumcision. Resulting in sexual reassignment of a male (XY), to a Female (XX). Normally includes use of hormone therapy, and results in phyco-sexual abnormalities.
Example 1
Mike: Man, that chick looks like a total dude.
Andrew: Yeah, she most likely has an ablatio penis.

Example 2
Mike: Hey lets go out tonight and get trashed.
Andrew: Nah, Im just going to stay in tonight.
Mike: What do you have an Ablatio Penis?
by Michael Schmidtt January 26, 2009