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1.
Similar to a 'Spliff', a jeffrey consists of many other drugs including marajuana, crushed up E's, opium, Heroine, Angel dust etc. There is not a set drug ratio for the Jeffrey it is decided by the producer of the Jeffrey.

Recently featured in the new movie Get Him to the Greek.
A Jeffrey
by Natedawg18 June 27, 2010
 
2.
This is when you want to go for a banging poo, and after you look into the lou and you are proud of what you have achieved.
" Arrr man i need a banging Jeffrey"

" Did it hurt when you had A Jeffeys"

"Woo man that was one of the best A Jeffreys i have ever done"
by Howey bells October 22, 2009