Top Definition
The main highway in Houston used by most people to commute to work or go downtown...often referenced in a lot of houston rapper's songs such as Paul Wall, Mike Jones, Slim Thug...the word is orally pronounced "Five-Nine"
Sittin on that 59 South baby, PO'D up off dat texas tea
by Bizzle187 July 22, 2006
5 Words related to 59 south

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