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1.
What people say when they throw a deck of cards on the floor/across the room with no intention of picking them up, leaving the job to you. This usually happens after someone loses a card game multiple times and can't take it anymore. Or when you're just in the mood to make some people POed.
Shane: "Black Jack!"
Me: "What!? Again!? That's fourteen times in a row!"
Mikey: "Stop being a sore loser."
Shane: "Yeah, really. It's not like I cheat."
Me: "Yeah well," *gathers the deck of cards, "52 Pick-Up!" *Throws the deck of cards across the room and onto the floor, walks out of the room*
by Carrera's Wedge April 12, 2007
47 6
 
2.
A practical joke disguised as a card game. You would ask your friend if they want to play a card game. They'd probably reply saying "Sure!". Now, you'd scream "52-Pickup!!" and chuck the cards across the room.
Me: Hey Trevon! Wanna play a card game?
Trevon: Yea, nigga, let's go.
Me: How about 52-Pickup?!?! *Throws the deck of cards at his cornrows* What now, bitch?
Trevon: Nigga, I'mma beat cho ass.
by Quilava126 October 27, 2007
31 9
 
3.
A drinking game which involves a group of friends and a deck of cards. Each person picks up a card from a face down pile. The person, with the lowest card has to take a half shot (recommended) or full shot of tequila. Game ends and/or resets when all cards are picked up.

Recommended number of Players: 4+
(any less and the game will end too quickly)

Drink Responsibly
You guys want to play 52 Pick-Up?

Lets play 52 pick up.

You heard of 52 pickup? Its a drinking game.
by Jagaimo the Bandit February 03, 2010
8 10
 
4.
When you shove as many cards into the girls vagina as possible, then after you fuck her, play 52 pick up inside her.
While Garcia and Ajax were fucking, Hotrod decides for them to play 52 pick-up. We only got 47 cards in, but it was still fun.
by Eric Thumbsucker October 14, 2007
13 49