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1.
a fucking cannon with a pistol grip.
if you are up to 20 feet away and i shot at you with a "44 magnum" and missed by as much as five feet you would wish you were dead due to the awesome force that flys by after one of the cartriges have been detonated.
by joe penley March 03, 2004
 
2.
A pretty powerful pistol. Highly popularized in the Dirty Harry movies and described as "the most powerful handgun in the world" even though it was not.
I know what you're thinking. "Did he fire six shots or only five?" Well, to tell you the truth, in all this excitement I kind of lost track myself. But being as this is a .44 Magnum, the most powerful handgun in the world, and would blow your head clean off, you've got to ask yourself a question: Do I feel lucky? Well, do ya, punk? -- Dirty Harry (1971).
by JurisDoctorJ December 15, 2007