Top Definition
345 Disease happens when the body starts slowy shutting down all of its major organs until a person quits or locates a new place of employment.
Employee 1: Where's Mike at today?
Employee2: He had to quit cause his lungs started to shut down on him.

Employee 1: My liver stopped working at my last job.
Employee 2: Yeah man, that 345 Disease is no joke!!
by JGL January 14, 2014

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