Top Definition
Originating in Mankato Minnesota, Matt R was credited with the term. The term refers to nutting on someones face. While the word is known by only locals, "321 Up On It" has been found being used in day to day conversations.
Jeremy: That chick is a fucking cow, i wouldn't touch that with a if i was wearing a fucking astronaut suit.

Ben: Phhhh, I'd 321 Up On It...

Jeremy: That's buck nasty, why would you do that?

Ben: Spite.

by ThaMasta August 24, 2008

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