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1.
During the 1920's in the United States the social group that came to be known as "flappers" often used this phrase as a means of telling someone to "get lost," or to "scoot."
Flapper Guy: "Hey doll your dreamboat just sailed in..."
Flapper Girl: "23 Skadoo you soda jerk!"
by THEREALJULIA March 10, 2006
 
2.
a term used by kitty foreman on that 70's show. pretty much the best expersion ever.
sam "i didn't have to go to that hellhole called work today!!"
hannah "well 23 skadoo"
by miss darling July 04, 2007