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1. 222
a hotel room used for women you just met...usually a cheap hotel that costs about $29/night
D: Hey Yo Tony...lets get us an ol' 222 (two twenty two) for these girls we meeting tonite!

T: Aight yo
2. 222
meaning marijuana, or any kind of drug.
pothead:"Hey guys, u wanna take out the 222?"
Friend:"Hell Yeah, I got the bong."
3. 222
An exit off of 75.
St. Helen
The saying goes, Fun for you at 222, no fun for you at 942.
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