.22 

A common caliber of rim-fire weapons. This is often thought to be an ineffective caliber by people who cannot hit what they are aiming at. Used properly, it can be extremely fatal, especially with high-velocity ammunition.

The burglar died from a single shot to the head from a .22 pistol.

.22 by BlastMaster May 16, 2003

.22 

A popular calibre of firearm that size for size, does some of the most damage of them all.

My Ruger 10-22 is a very dependable rifle.

.22 by tradesman June 7, 2003

22 

The number of love. When two people fall in love, the number 22 will follow you. If you see a 22, that means that the person you are in love with is thinking about you.

Listening to Love Story at 12:22 in the afternoon.

22 by 122206 January 18, 2010

22 

The age after 21 where you realize you still have another 3 years to get your shit together

Haha I'm only 22

22 by Jeri Lei August 11, 2008

22 

the number of princesses

wow look at that princess over there. he most love the number 22.

22 by theshackisbeastly August 25, 2010

.22 

Pistol or Rifle using .22 bullets. Do to it's small size, it has no stopping power, but is obviously much more accurate. If used correctly, is an extremely lethal weapon.

That dumbass with the .50 shot 6 times at me and miss, so I just popped on .22 and he was down.

.22 by A guy. April 3, 2005

22 

1) A .22 caliber handgun
2) Any rim that measures 22 inches in size
3) Slang term used for women to let you know they are prostitutes.

1) Don't tote no 22's
2) Magnum cost me 22, sat it on them 22's
3) Lil mama super thick, she say she 22

(All examples from Rick Ross' Hustlin)

22 by TheChef May 12, 2006