22
VTA Line 22, a bus route that goes between Menlo Park and eastern San Jose (more specifically, Eastridge Mall) along El Camino Real, The Alameda, Santa Clara Street, Alum Rock Avenue, King Road, and Tully Road. It is one of the longest and most well-known bus routes in the South Bay region of the San Francisco Bay.

The 22 runs more frequently than any other bus route--buses show up every 10-15 minutes during the day, and the route operates 24/7. Additionally, it is the only bus route that uses bendy buses.

Unfortunately, because of the 24/7 schedule, bums and smells reminiscent of shit are pretty common, especially at night. As a result, the 22 has come to be known as "Hotel Deuce Deuce," "the Felon Express," among others.
I stepped onto the 22, and got out in 3 seconds flat. I'd rather take a cab home.
by G-Suck68 October 16, 2007
22
A number after 21 and before 23
Also an annoying song recorded by former country- now pop artist Taylor Swift
And keep dancing like we're- 22!
by Someone who's smarter than you December 23, 2014
22
The best number in the world. Looks absolutely perfect on a sports uniform jersey. Usually worn by the best player on the team.
Me: Can I PLEASE PLEASE PLEASE have my number??!
Player with #22: I would but, sorry no.
Me: *cries all the way home*
Legit^^^
Mom: Why are you mad?? (Wasn't at practice)
Me: BECAUSE MOM. IM GOING TO BED. GOODNITE.
by basketballer22 December 03, 2013
22
22 (noun), 22ing (verb)- The act of sitting on another man (face to face) while both participants attempt to defecate into a toilet. Similar to the 33, where one or both participants have erections during the act of 22ing.
"I will 22 you."

"I just 22ed that guy"

"Hey what if you got an erection while 22ing?"
by just22ed May 04, 2009
2-2
The female genitalia. Comprised of two inner lips and two outer lips, which make up the 2-2. Also known as {tutu}, or two-two, this term is often used in place of more crude choices such as {pussy}, {cunt}, or when speaking to children - in place of anotomically scary or mature words such as {vagina}.
"Let's {69}! I will put my mouth on your {tool}, and you can put your mouth on my 2-2!"

"Okay Sally, remember that when you take a bath, you have to wash your 2-2 really well."
by Shae D October 19, 2006
2.2
a number refering to speed (usually in seconds); relating to a small amount.
"i'll be back in 2.2"
"gramps over here is driving like 2.2 miles an hour!"
"he's only been with 2.2 people"
by Anonymous April 13, 2003
22
a 22cm cock
Oscar has a 22
by dee-dubz November 12, 2009
22
When one of your friends is so messed up that he is no longer known as a person, so is now called by a number.
Damn look at 22!! i cant believe hes rolling around in his puke.
by dotrat93 May 22, 2011

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