VTA Line 22, a bus route that goes between Menlo Park and eastern San Jose (more specifically, Eastridge Mall) along El Camino Real, The Alameda, Santa Clara Street, Alum Rock Avenue, King Road, and Tully Road. It is one of the longest and most well-known bus routes in the South Bay region of the San Francisco Bay.

The 22 runs more frequently than any other bus route--buses show up every 10-15 minutes during the day, and the route operates 24/7. Additionally, it is the only bus route that uses bendy buses.

Unfortunately, because of the 24/7 schedule, bums and smells reminiscent of shit are pretty common, especially at night. As a result, the 22 has come to be known as "Hotel Deuce Deuce," "the Felon Express," among others.
I stepped onto the 22, and got out in 3 seconds flat. I'd rather take a cab home.
by G-Suck68 October 16, 2007
Zigzags or rolling papers. Each 2 represents a z, and can be used to keep a cover on what you're actually trying to do
"Hey while you're at the store can you grab me a pack of 22's? We need something to smoke."
by stellato4 January 11, 2008
.22 caliber.
A small rimfire cartridge, used for target shooting.
Three variations of .22 caliber exist: .22k (short), .22lr (long rifle), and .22WinMag (Winchester Magnum).
Sometimes used incorrectly to refer to a derringer, which is often chambered in a larger caliber.
"He didnt think I was packing, so I busted out my 2-2 and copped me a 187"
by .357ROB September 30, 2003
the act of having sex.

Sex was seen as entry #22 of a list on relationship building strategies. Many wondered why it was not #1.

Alone is 11.

twice is 44.

44 has also been used to mention the act of 22 with 4 or more consenting adults.
Hey honey, let's put the kids to bed and go have some 22.

This party is getting dull, let's slip away into a dark corner for some 22.

Do you want to see if that couple over there wants to 44?
by mightyacorn January 14, 2010
a very annoying phrase used by retards describing how fast something is going to be done
"im going to abercombie ill be back in 2.2"
by ben April 01, 2005
A number after 21 and before 23
Also an annoying song recorded by former country- now pop artist Taylor Swift
And keep dancing like we're- 22!
by Someone who's smarter than you December 23, 2014
The number seen often that symbolizes best friends. When seeing a 22 on random objects or at random times, you should stop and inform your best friend that you are thinking of them.
Best Friend #1: Orders Starbucks and the bill totals $4.22
Best Friend #2: Received a picture on their cell phone of the bill and thinks "Ohhhh, my best friend is thinking of me"
by Kim1Champ August 02, 2010
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