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1.
Acknowledgment that someone just did or said something stupid.

Usually said in a sarcastic and demeaning tone.
Mississippi resident: “Dude that shvelby (mullet) is tight he must pull all the fine bitches!”

Any one else: 2 4 It, F#&$ inbread idiot.

Other example

Seattle resident: I am going to put a definition on Urban Dictionary.

Friend: 2 4 It!
by Eno21 February 13, 2008