Suffix often added following the first consonant of a word to increase the "coolness" of speech. "-izzle" can also be used to replace the last syllable of a word.
How the suffix functions with single syllable words beginning with a vowel (i.e.: up) is unknown.
Origin is said to be from popular African American rapper Snoop Dogg who decided to modify the current English language to increase its ability to convey thoughts, ideas, and expressions.
"Oh yeah man, a 300 piece pizzle!"
"Why did you add -izzle to puzzle?"
"Shizzle *up* mizzle fizzle."
Black urbanite: OH, I'm fo schizzle my doggy bizzle... I hooked up with some hizzles and got some 40 ouncizzles and I'm going to fizzle those hizzles in their tight little vagizzles!