A variable of the ^.^ or ^_^ face. Most coming from someone who is trying to cuten up the face by adding whiskers. This gives a cat like effect.
user 1 : Did you see the kitty??
user 2 : w00t.. lookit teh kitty =^.^=
kitty smiles. like neko or anime wink. mean your happy,joyful,playful,excited...etc
Person:hi friend whats up!
Me:hi long time no see! =^.^=
person:wanna play a game? =^.^=
Me:sure why not?