2.) To fuck somebody.
3.) A bad word.
4.) A bad place.
John: You high Jack? Only :O people go there.
Johhny: Yeah and it's the teacher's favorite place.
Jack: Yeah i think i changed my mind.
Or, used to indicate surprise or shock by the author of a comment.
I can't believe you've just told me I have a bejesus of a big ass! :-O