means taking a shit or scat, droppin' bombs (not in the George W. Bush sense of the word).
note: See the first Austin Powers movie for a funny joke about #2. When Austin is fighting an agent on the toilet, he says "Who does #2 work for?" The character (played by Tom Arnold), in the next stall, says (paraphrase) "Way to go! You tell em' who's the boss"
cf. #1 or number one
2.waste that you let out while on the toilet, usually brown, green, or yellow.
3.can be a hard or running excretion from the anal.
Lucy: Yes, but what do you have to do?
Kelly: I have to do #2.
Lucy: Eww. Use some air freshner cuz I don't want to smell that.