fo shizzle my nizzle translates into "I will definitely acquiesce indubitably in the said activity such as drinking cool aid, grape soda, orange soda, KFC, watermelon, waffles, and various other food items".
Boo: Yo, would you like to participate in the consumption of Kentucky Fried Chicken, while consuming a 40 oz alcoholic beverage in the back of my vehicle that has the bass so far up that whenever I commute near a seismographic station, there seems to be a 10.7 on the Richter scale in Ethiopia.
La Fawnda: Fo shizzle my nizzle.
Boo: Well, that sounds swell to me. Let us hop in and endear in the lovemaking in the opposite sex.
by kevk77 March 15, 2009
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fo shizzle my nizzle
for sheazy my neazy
for sure my nigga(z)
for sure my african-american friend
r u still comin ova 2 me hows 2moro heh?
ye man fo shizzle my nizzle
by tne_young_niggaz June 11, 2004
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for sure my African American friend; popularized by Snoop Dog, but originating in African American communities to accommodate rhyming words which didn't have enough syllables
Alicizzle izzle blizzle than yizzle.

This new doggyfizzle televizzle gon' be off the hizzle, fo shizzle my nizzle
Translation: This new Snoop Dogg television show is going to be off the hook (meaning great), for sure my negro
by thebeautifulone May 4, 2009
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fo shizzle my nizzle, or fo hizzle my wizzle, tranlates to: for sure, my nigger OR for sure my white-nigger. its mostly used by snoop dogg, dr dre, and eminem.
jay-z: "fo shizzle my nizzle used to sribble down in v.a"
by niggerina_hannah August 19, 2006
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The mean of Fo Shizzle My Nizzle is For sure, my nigger. often used when a Gangster or some sort of black person (or in some rare cases a white person) says it to his friends to make him seem cool or "gangster"
Rick: you sup joe
Joe: nutt'n much you?
Rick: same.... Oh shit its billy i hate that fag...
Billy: Yo Fo shizzle my nizzle dog
by Nomad guy February 1, 2009
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