When a woman is especially hungry for the male reproductive organ.
A nympho would be the classic example of a woman who is cock sick.

If you are talking about a cock sick woman in from of her but do not want her to know what you are talking about, you can use "toxic" instead, that way she might even think you are complimenting her, further increasing her cock sick rage.
Dude1: This girl is all over me mayn, and all mah boys.

Dude2: Damn yo, bitch is cock sick.
by snipedogg June 2, 2010
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