Can be used in two ways:
1)To refer to an obese woman's camel toe.
2)To refer to a man who is splitting his package in two with the seam of his overly tight pants.
the appearance of a large wedge in a womans genital region resulting from tight fitting clothes. Similar to a Camel Toe, but a Moose Knuckle is bigger.
"Damn, look at that girls tight shorts, you can see her moose knuckle."