When a guy stays arm-in-arm with his girl all night long at the club (or any public place), trying to keep other guys from talking to her. For instance, he might walk her to the bathroom, then stay outside the bathroom waiting for her, then walk her back to the dance floor.
In R. Kelly and Bow Wow's song "I'mma Flirt," there's a verse that goes "cuff your chick." Basically he's warning guys to "cuff their chicks" cause he's a flirt! >;-P