A public university in Terre Haute, Indiana that is usually one's back up school to their back up school. No true academic reputation like the other public schools in Indiana. The only people who will go here are those who never tried in high school, causing them to be rejected by Purdue, IU and Ball State, or college drop outs. Hence why it's acronym, ISU, truly means "I Screwed Up."
Random guy: "Where do you go to school?"
Indiana State University student: "I use to go to Purdue, but I couldn't handle it and dropped out, so now I'm at ISU."
Random guy: "What's ISU?"
ISU Student: "I Screwed Up"