Primarily for movie goers, the pre-pee is when one goes to the bathroom before getting the movie starts, in order to avoid having to go to the bathroom in the middle of a movie and miss a good part.
(while on premiere line)
A: I heard this movie is dumb long
B: Yeah, 3 hours or something
A: I'm gonna go pre-pee. Hold my spot?
B: Yeah, sure. I'm next though.
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