1 definition by pointdexter81

Top Definition
Refers to the area that is south of Market Street (hence, "soma") in San Francisco, CA. Once strictly a gritty industrial neighborhood, the area has maintained the grit while developing into a thriving nightclub and residential/work-live loft area. Was also the location of many failed dot-com companies and is still home to a number of gay bars.
If you're looking for booty, check out My Place and the Powerhouse in soma.
by pointdexter81 September 25, 2003
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