A clan in Vampires: The Masquerade by White Wolf. Renown for two things. The ability to craft flesh and bone, to essentially use their hands to change some one elses body or even their own. Knwon also for war ghouls, three or more humans fused together into one creature.
Also renown in the V:TM world for their extreme cruelty and inventive torture methods. Very territorial. Work in the Sabbat, letting the Lasombra take the majority of the heat.
Known to dislike the Tremeres as mage rivals.
Woah. That Tzimisce elder just made that guy into a crawling arm... ouch.