Originated as a descriptor for the labor of harvesting cotton crops. Later used to described the farm-workers, primarily african-american slaves, who harvested the crops. May be offensive, and perceived as derogatory or insulting, to any intelligent or enlightened audience if spoken aloud.
"Are you out of your cotton-pickin' mind?" "Assembling IKEA furniture is so cotton-pickin' hard if you don't follow the instructions." "My boss is such a cotton-pickin' fool."