"Mole" can mean several things
1) A mix of marijuana and tobacco that is smoked out of a bong, usually the whole mix is smoked in one rip. The ratio of marijuana to tobacco can be what ever the smoker wants; when it's all tobacco it's called a slappy.
2)If the C in Cole was replaced with an M, then Mole is the word.
3)A small mammal that is designed to dig.
4)The number 6.022 x 10^23. This "Mole" number can refer to any number of a certain type of entities.
1)"Pass that american spirit tobacco so it can mix with this chronic and then get smoked in a single bong rip."
3) Dad Guy: "That mole has been digging all sorts of holes in our yard"
4)Beginner chemist: "There's 6.022 x 10^23 atoms in thats grain of sand"
Senior chemist: " Ah. That means there's 1.000 mole(s) in that grain of sand"