a girl, (or a boy i suppose), who just ain't all that.
Also, easyrough, the kind that are slightly too friendly, whilst being far from eye candy, creating an uncomfortable feeling as you try and escape.
Also, to describe the general attractiveness of a club/bar/area.
To pull a not so hottie, "Unlucky..You got your ruffruff on last night"
"it was a bit 2ruff in there last night..."
Any form of nasty disease or extremely unpleasant (illness related) feeling, (of course including AIDS)
"Jeez I shouldnt have eaten that, feel like I have super AIDS"