1. When the electricity goes out, and people who have been used to always working begin to freak out.
2. When people used to constant electronic access, lose their devices (temporarily or permanently) and go through rapid withdrawal.
1. Ann: Have you seen the way Bob has been acting lately?
Jake: The power is out. What do you expect? It's Grube Syndrome.
2. Robby: Why is Andrew acting so crazy?
Allen: His parents took away his laptop because he got a C in Economics. He's going through some serious Grube Syndrome.