When someone does something that is so sad and retarded that you lose all hope for humanity.
It can also be a bad attempt at appearing tough or intimidating.
guy 1 - "Someone called me last night as restricted, called me a pussy, giggled then hung up.
guy 2 - "That's pretty tewksbury."
guy 1 - "Looks like mike is wearing his black beater again to the gym."
gym 2 - "I'm sick of all the tewksbury this guy tries to pull."