1) An agreeable response to a problematic situation in which the situation is out of the control of the responder or both parties.
2) A somewhat regretful, conflicted response to a decision already made or one that is currently being made by the responder.
Person A: I REALLY wish you didn't live so far away:(
Person B: I know.. me too:/
Person A: So you're telling me you cheated on me?! But why?
Person B: I don't know what to say:/