"P.Y.T." was famously referenced by President Ronald Reagan during Jackson's 1984 White House visit, saying "Let's give some T.L.C. to the P.Y.T.s."
The song was sampled by Monica on her 2002 single, "All Eyes On Me."
The chorus of the song is also used in the song "I Wanna Love U" by Memphis Bleek, from his album M.A.D.E., sung by Donell Jones.
In the beginning of the song, Jackson whispers, "You know, you... you make me feel so good inside. (chuckles) I've always wanted a girl just like you. You're such a P.Y.T., Pretty Young Thing".
Almost at the end, he says, "You know, I think I'm nice enough. You I could've, you know, just get together. You're such a P.Y.T. to me. Pretty Young Thing." At the end he says, "I just want to love you, you know. (chuckles) I'll give you all that I've got."