1) two of Jim Henson's muppets. They are cranky, cantankerous old men who go out of their way to make everyone near them miserable.
2) two people who resemble the characters Statler and Waldorf in their behavior.
3) two people who pester, harass, and nettle the people around them because they have literally nothing better to do.
"Wow, do Skimmel and Sean ever shut up? They're just as obnoxious as Statler and Waldorf!"
"Don't feel bad hon, Draknar and Shalok always act like that. They're Statler and Waldorf."