A Tweezle is someone who drinks excessively, despite warnings from their friends. To be a Tweezle, one must not only completely disregard their own limits, but also the civilised demands of their friends to the point where they vomit and coma and people reluctantly have to look after them, and clean up their putrid vomit. Added points if they do this more than once, then think they're cool for doing it.
1: 'Hey, look at the vomit on the wall of the shower!'
2: 'Yea, somebody Tweezle'd'
1: 'man, that Tweezle should be ostracised for sure! What an inconsiderate twat.'