Poor variation on the popular replacement of "'Sup my nigga" by "Shizzle my nizzle." Humor value is achieved through the word nozzle, which could easily sound like "suck my dick" if interpreted improperly.
Dude 1: Sup yo.
Dude 2: Shozzle my nozzle.
Dude 1: Dude, I dont swing that way slaps Dude 1