One of the main and most important characters on the medical drama House, M.D. He is called 'Wilson' by most and is House's best friend. There is a large fandom surrounding the House/Wilson relationship and the writers have admitted to putting some subtext involving them into the dialogue.
Dude, did you see James Wilson's hair yesterday?! CRAZY SHIT!!
Stacy: What are you hiding?
House: I’m gay
House: Oh that’s not what you mean. Does explain a lot though, no girlfriend, always with Wilson