In addition to being a term for good marijuana, or getting knocked with a single punch, its also a phrase for anything that has a sudden impact. For instance, a disastrous tornado or hurricane would be described as a one hitter quitter. Or an athlete or athletic team particularly in football. Such as Barry Sanders or Reggie Bush who can go the distance for a touchdown at any given moment is known as a One Hitter Quitter. A team with a high powered offense attack,like the Oregon Ducks would be known as a One Hitter Quitter
" The game is close right now, but USC better stayed on their game, Oregon got that one hitter quitter"
"Man I think we need to evacuate, I hear that hurricane thats coming got that One Hitter Quitter"