1. An expression, origionally taken from Samuel L. Jacksons snakes on a Plane, showing great anger towards someone or something
2. A universal expression able to be used anywhere for anything.
1.Tom: Hey anthony, i ate your food
Brian: And Anthony, I stole your iPod.
Anthony: BAH, you guys are muther fuckin snakes on a plane!!
1.Greg: Fuck you anthony, you forgot to go running today.
Anthony: OMG!! Snakes on a plane!!