A job or many jobs that require a lot of hard, mostly physical, work. The term usually refers to driving long distances from one place to another for an unwanted cause.
Joe: Hey, we're going to play some football! are you coming?
Nitz: No man, I need to drive my brother to the airport, and then to take the car to the garage.
Joe: What a kanias.
Nitz: You bet your ass.