To cowboy-up, to man-up. To stop being a pussy and start acting like a man....with a dick
Bob: She's hot, but I'm afraid to talk to her.
Jaqrell: Put your dick on and talk to her.
Used to show a favorable attitude or agreement. Can also be used in the same way as "straight" or "its cool".
Person 1:Joe's mom is out of town this weekend so party at his house.
Person 2: Setttttttttttttt!
Person 1: She thinks your flaw
Person 2: Set. I don't give a fuck
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