1) Totally insane.
2) Rushed or hurried. Busy.
3) Out of control.
1) Yo, that girl from last night won't stop calling me!! She's nuts as balls!
2) We had this huge shipment come in late last night and had to get everything moved in before our shift ended... It was nuts as balls!
3) My brakes went out on the way over here... It was nuts as balls!