The Main Street, originally the retail centre of the town, has become a centre for popular night clubs and pubs, voodoo in particular has attracted figures such as Sander Van Doorn, Markus Schulz, Paul Van Dyk, Eddie Halliwell and Marco V in recent years. The locals have there own slang which is commonly used.
Letterkenny is one of the worst towns in Ireland for public order offences. There were a total of 777 public order offences recorded in the town in 2003 with 1505 recorded in 2008. These statistics place Letterkenny as the sixth worst town in Ireland for public order offences, worse than the notoriously dangerous Dublin suburbs of Coolock and Clondalkin.
The Main Street has seen numerous assaults, stabbings, sexual assaults, drug raids and attacks on Gardaí in the past. Drug crime has become a problem in recent years, notably in the now demolished mart building.
The three main shopping malls are the Courtyard Shopping Centre, the Forte Shopping Centre and the Letterkenny Shopping Centre, the latter being the oldest. The Main Street is home to many older establishments including R. McCullagh Jewellers, dating from 1869, and Speers Department Store.
The Letterkenny Institute of Technology (LYIT; known locally as the Regional) is one of the largest institutes of third level education anywhere in Ulster.