Anything sickness that makes you feel terrible. Stomach virus, flu, ebola, etc.
Person 1: I HAVE EBOLAIDS HELLPPP MEEE!
Person 2: ...You are talking in all caps.
Person 1: No for serious I'm going to like, die. You don't even know. If I throw up on your shoe, will you still like me?
Person 2: ...No.