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1 definition by Young Chizzy

acronym for "You Only Live Once"; has recently become overused due to the popularity of its use in Drake's "The Motto"; particularly overused by chicks on Facebook and Twitter who use this term as secret code for "we're down for anal"
Guy: Wanna go out tonight

Girl: YOLO!

Guy: Hell yeah, dat ass!
by Young Chizzy May 04, 2012