1. When someone or something pisses you off. Like a pain in the ass but worse.
2. When something may cause your dick much pain.
1. "Cheryl, stop being such a pain in the dick."
2. Duffman- "Ya'll hear about suzie?"
Burnsy- "No what?"
Duffman- "I've heard she has vaginal teeth
Burnsy- "What a pain in the dick."