Big Pun along Billy Danze and Lil Fame (the latter two comprising M.O.P.) are new york giants; a head and shoulders above the industry, the game, new york, and the world.
Possibly inspired by the football team of the same name.
The song appears on Pun's posthumous album Yeeeah Baby
"New York giants
Leave 'em brainless!
Hit 'em with the stainless!
It's the world famous!"