The worst thing a man can hear from his woman. It undoubtedly signals the oncoming of a long drawn out conversation about how you don't have a vagina and how she doesn't understand that. Other features are senseless bitching about her ridiculous insecurities that defy logic and rationality.
Woman- "Are you busy? Because we need to talk"
Man- "FUCK!"...."I mean, sure honey."
"Dammit, now I have to pretend like I care for another bullshit conversation."