A state of total and utter annihilation resulting from excessive substance abuse involving the following: excessive binge drinking followed by a sufficiently debilitating blunt smoking session.
Guy A: Man, we are getting twisted up in hur'.
Guy B: Dude, I am so blunked out.
Guy A: Wow, you must done an excessive amount of binge drinking and then followed it up with a smoking session...possibly with a blunt.
Guy B: (throws up)